Reference Guide

EDS : Ehlers -Danlos syndrome 

  • A genetic disorder that affects the production, processing, or components of the connective tissue
  • Symptoms include widespread and chronic pain, fatigue, injuries and dislocations from daily activities, delayed healing, skin sensitivity and fragility, digestive disorders, allergies, immune disorders, and disorders of the autonomic nervous system
  • There are many defined and undefined types of EDS, more research is needed to determine all genes involved
  • There’s a wide spectrum of EDS severity
  • Every system in the body can affected by EDS

POTS: Postural Orthostatic Tachycardia syndrome 

  • A form of dysautonomia,  improper functioning of the autonomic nervous system commenly a comorbidity of EDS
  • The body gets stuck in sympathetic overdrive, fight or flight mode upon standing or being upright
  • Symptoms include rapid heart rate, dizziness, fainting, brain fog, digestive distress, exercise intolerance, and feelings of anxiety
  • Thought to be caused in EDS by blood pooling in the lower limbs due to lack of natural compression from the surrounding tissues
  • Also a spectrum disorder, some patients may live seemingly normal lives only getting dizzy spells after standing for extended periods of time while other patients are completely wheelchair bound

MCAD: Mast Cell Activation Disorder 

  • An excess and inappropriate response of the mast cells to allergens, toxins, and chemicals
  • Affects the skin, respiratory and digestive system
  • Symptoms include itchy, flushing, hives, rashes, nausea, drops in blood pressure and anaphylactic responses
  • Also a spectrum disorder, some patients get frequent cases of hives while others have full blown anaphylactic reactions
  • There are medications available to help decrease the activity of mast cells and lower the bodies histamine levels

*Note these three disorders are overlapping and intertwined in ways which are not yet understood